Russ and his girlfriend Samantha are finally back together. She took him back after he'd been cheating with her sister, Jo. Who used to be Joe, before Russ started delivering a gender-bending hormone treatment to her. But when Jo drops a dose of the hormone into the wine for revenge, will it be Russ who transforms...or will Samantha suddenly find herself incredibly well-endowed and ready to totally dominate Russ with her new equipment?