This, the 54th issue of Transactions on Large-Scale Data and Knowledge-Centered Systems, contains three fully revised and extended papers and two additional extended keynotes selected from the 38th conference on Data Management - Principles, Technologies and Applications, BDA 2022. The topics cover a wide range of timely data management research topics on temporal graph management, tensor-based data mining, time-series prediction, healthcare analytics over knowledge graphs, and explanation of database query answers.