Suspect acute leukaemia in patients with anaemia, neutropenia, thrombocytopenia and associated systemic symptoms such as infections and bleeding, particularly mucosal bleeding.Advanced acute leukaemia is characterized by poor general condition of the patient, leucocytosis and immature blast cells in the blood.The establishment of precise diagnosis and the initiation of urgent treatment take place in a specialized hospital. Post-treatment follow-up is carried out in the hospital outpatient clinic and later in the primary health care.