The 37 revised full research papers, included in the volume were carefully reviewed and selected from 103 submissions. They are organized in the following topical sections: Transdisciplinary Research & DSR (theme Track); Blockchain Information Systems; Intelligent Systems and Human Interaction; Healthcare Systems and Quality of Life; Innovation and Entrepreneurship; Sustainability and Responsible Design (Environmental Issues, Human Values and ethical Design); Human Safety and Cybersecurity; Emerging DSR Methods and Processes; Designers and Collaborative DSR; and Education and DSR.