Cytochrome P450
John B. Schenkman · Helmut Greim
märts 2013 · Handbook of Experimental Pharmacology 105. raamat · Springer Science & Business Media
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In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammalian to birds and fish, to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest to the reader are, for the first time, a compilation of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis. This volume presents the most complete survey of the cytochrome P450 field. It will allow recognition and understanding of the very wide implications this enzyme system has on life processes.
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