Pharmacokinetics and Metabolism in Drug Design: Edition 2

Han van de Waterbeemd studied physical organic chemistry at the Technical University of Eindhoven and did a Ph.D. in medicinal chemistry at the University of Leiden, The Netherlands. After a post-doc with Bernard Testa at the University of Lausanne, Switzerland, he became a faculty member for 5 years and taught medicinal chemistry to pharmacy students at the universities of Berne and Basel, Switzerland. In his pharmaceutical career he worked for Roche, Pfizer and Astra-Zeneca where he is now global project leader of their platform for in silico predictions of ADME/Tax properties. He published more than 133 peer reviewed papers and book chapters, and (co-) edited 11 books. His research interests include the role of physicochemical and structural molecular properties in drug disposition and in silico modeling of ADMET properties.

Don Walker has a degree in Biochemistry from the University of London and spent four years assisting research involving the biochemistry of inborn errors of metabolism. He joined the Drug Metabolism Department at Pfizer in Sandwich in 1986 and since then has contributed to the drug metabolism and pharmacokinetic evaluations on several drug discovery and development projects including amlodopine, dofetilide, sildenafil, variconazole and maraviroc. He has published numerous papers on drug metabolism and pharmacokinetics and during his career at Pfizer he has been an active contributor to the UK Drug Metabolism Discussion Group, at various times having served as committee member, chairman and course tutor.