Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Paola Lecca · Ian Laurenzi · Ferenc Jordan

2013年4月 · Elsevier

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Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics.

Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples
Presents recently developed discrete stochastic formalisms for modelling biological systems and processes
Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics

作者简介

Paola Lecca is a researcher at The Microsoft Research, University of Trento, Centre for Computational and Systems Biology, Italy. Her principal research interests include biochemical system identification and model calibration, stochastic chemical kinetics and reaction-diffusion system.

Ian J. Laurenzi is a Senior Researcher at ExxonMobil. He is an expert in the areas of stochastic processes, statistics, computational biology and receptor-mediated adhesion of human blood platelets, and has investigated the genome-level dynamics of gene networks and the effect of sex upon mammalian gene expression.