Diabetes and Cardiovascular Disease: Edition 3

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The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

저자 정보

Dr. Michael T. Johnstone, MD, is the Director of Clinical Cardiology and Director of the Cardiology Fellowship Program at St. Elizabeth's Medical Center, and an Associate Professor of Medicine at Tufts University School of Medicine. Board certified in internal medicine, cardiovascular disease, vascular medicine, nuclear medicine, echocardiography, cardiac CT and vascular ultrasound, Dr. Johnstone specializes in coronary artery disease, diabetic heart disease, general cardiology, non-invasive cardiovascular imaging, and valvular heart disease. He earned his medical degree in 1982 from McGill University in Montreal, Canada and did his residency at Montreal General Hospital. He completed his Cardiology Fellowship at McGill University, the Montreal Heart Institute and the Brigham and Women’s Hospital. He spent 7 years as the Director of the Diabetes and Cardiovascular Program at the Joslin-Beth Israel Deaconess Medical Center. His research interests include non-invasive imaging, atherosclerosis, acute cardiovascular disease/ plaque disruption and diabetes mellitus.

Michael Johnstone, MD, CM, FRCP(C), FACC, FAHA, FVSM, FASE, FASNC,

Director, Cardiovascular Fellowship Program and Clinical Program

Steward St. Elizabeth’s Medical Center
Associate Professor, Tufts University Medical School736 Cambridge St.Brighton, MA. 02135

Dr. Aristidis Veves is the Director of the Rongxiang Xu, MD, Center for Regenerative Therapeutics and the Research Director of the Joslin-Beth Israel Deaconess Foot Center and of the Microcirculation Lab, and Rongxiang Xu, MD Professor of Surgery at Harvard Medical School. He received his M.D. from the Medical School, Aristotelion University of Thessaloniki (Greece) in 1981, his M.Sc. from the Faculty of Medicine, University of Manchester (U.K.) in 1991, and his D.Sc. from Athens Medical School (Greece) in 1993. Dr. Veves did his internship and residency in Greece. He then completed his Fellowship in Diabetes and Endocrinology at Manchester Royal Infirmary (U.K.) (1987-1993). In 1993 he moved to USA as a Research Fellow at Deaconess – Joslin Foot Center, Deaconess Hospital (Boston, MA) (1993-1995). He subsequently became Instructor (1995-1999), Assistant Professor (1999-2004) and Associate Professor (2004-2012) and Professor (2012-present). Dr. Veves’ main academic interest is diabetes complications including cardiovascular disease, neuropathy and foot ulceration. He conducts ‘bench to bedside’ research that is mainly funded by the National Institute of Health (NIH), DARPA, DoD and other non-profit organizations. The main aim of his research is to understand the pathogenesis of these complications can develop new therapeutic approaches.

Aristidis Veves, MD, DSc, MSc

Rongxiang Xu, MD, Professor of Surgery, Harvard Medical School,

Director, The Rongxiang Xu, MD, Center for Regenerative Therapeutics,Research Director, Joslin-Beth Israel Deaconess Foot Center,Beth Israel Deaconess Medical Center
Address: Palmer 321A, West, BIDMC,One Deaconess Road, Boston, MA, 02215

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