The book grew out of a series of the Shonan Meetings on this ambitious topic held in 2012, 2013, and 2015. The authors were active participants in the meetings and have brought in interesting points of view. After several years of reflection, they now have been able to crystalize the ideas contained herein and collaboratively pave the way for solving some aspects of the research problems. As a result, the book stands as a milestone to initiate further progress in this promising interdisciplinary research field.