Epigenetic Mechanisms in Cancer

Sabita Saldanha

Nov 2017 · Translational Epigenetics Book 3 · Academic Press

Ebook

392

Pages

Eligible

Ratings and reviews aren’t verified Learn More

About this ebook

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. - Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. - Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management - Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis - Features contributions by leading experts in the field - Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

About the author

Dr. Saldanha is an Assistant Professor in the Department of Biological Sciences at Alabama State University. Her current research project includes the therapeutic role of histone deacetylase inhibitors in colon and prostate cancers, and her areas of epigenetic interest include epigenetic markers as effective tools in cancer diagnosis. She has more than fifteen years of research experience in cancer epigenetics, protein biochemistry, molecular biology and cloning. She has twelve years of teaching experience and has been a STEM faculty mentor, MARC mentor, and Honor’s program project director at ASU. Recently, Dr. Saldanha was named the 2015 National Academies Education Fellow in Life Sciences. She is also currently a Health Disparities Research and Training Program Scholar at UAB and a member of the Cancer Biology Research and Training program at ASU, which was established in 2015. She serves as senior personnel for the ASU-UAB Comprehensive Cancer Center partnership and has been instrumental in developing a cancer biology course at ASU.

Rate this ebook

Tell us what you think.

Reading information

Smartphones and tablets

Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.

Laptops and computers

You can listen to audiobooks purchased on Google Play using your computer's web browser.

eReaders and other devices

To read on e-ink devices like Kobo eReaders, you'll need to download a file and transfer it to your device. Follow the detailed Help Center instructions to transfer the files to supported eReaders.

Report illegal content