Epigenetics in Oncology
eBook 정보
Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists, graduate students and clinicians alike.
저자 정보
Jun Lu, Ph.D.
Dr. Jun Lu is an Associate Professor of Genetics with tenure at Yale University School of Medicine. He is a Core Member of Yale Stem Cell Center, and a member of Yale Cancer Center and Yale Center for RNA Science and Medicine. Dr. Lu is also an Associate Director of the Cell Preparation and Analysis Core of the NIDDK-funded Yale Cooperative Center of Excellence in Hematology. Dr. Lu received his B.S. degree in 1997 from Nanjing University in China. He obtained doctoral degree in biochemistry at Boston University in 2003 and received postdoctoral training at the Broad Institute in Boston. Dr. Lu’s laboratory studies gene regulatory mechanisms involving small noncoding RNAs and epigenetic pathways. His laboratory uses multi-disciplinary approaches, including computational biology and wet-lab experiments, to reveal regulatory mechanisms in the areas of hematopoiesis and cancer immunology. His papers have been cited over 20,000 times, and he has an H-index of 38. Dr. Lu was an Alexander and Margaret Stewart Trust Fellow and a William Guy Forbeck Research Foundation Scholar.G. Greg Wang, Ph.D.
Dr. Greg Wang is Full Professor at Department of Pharmacology and Cancer Biology, Department of Pathology and Duke Cancer Institute, Duke University. He received his Ph.D. degree from University of California, San Diego, followed by a postdoctoral training with Dr. C David Allis at Rockefeller University. Before joining Duke in 2023, he has been a full-time faculty member since 2011 at Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina (UNC) at Chapel Hill. Dr. Wang’s research programs broadly focus on mechanistic understandings of how chemical modifications of chromatin (including DNA methylation and histone modifications) regulate gene expression and cell fate determination during development, and how their deregulations lead to human diseases, notably cancer. His laboratory recently identified and characterized novel proteins that specifically bind to histone lysine methylation. These histone modification ‘readers’ are crucially involved in gene and genome regulation, development, immunity, and/or cancerous transformation. Importantly, discovery of small-molecule inhibitors to target chromatin modulators has become an area of intensive investigation and holds great promise for therapies. Dr. Wang’s research excellence and expertise in the broad fields of chromatin biology and cancer epigenetics have earned him grant funding of NIH and private foundations such as an American Cancer Society Research Scholar, an American Society of Hematology Scholar in basic science, a Janet D. Rowley Medical Research award from Gabrielle's Angel Foundation for Cancer Research, and a Leukemia and Lymphoma Society Scholar. Greg Wang also receives the recognitions from the institute such as the Philip and Ruth Hettleman Prize for Artistic and Scholarly Achievement (2019, UNC) and the Yang Family Biomedicine Scholar (2020, UNC), as well as the American Society for Biochemistry & Molecular Biology (ASBMB) Young Investigator Award (2021). One of Dr. Wang’s research goals is to yield potential drug candidates with preclinical cancer models, which shall pave a way for translating new therapeutic approaches in future.
