Molecular Analysis of B Lymphocyte Development and Activation
Harinder Singh · Rudolf Grosschedl
Mar 2006 · Current Topics in Microbiology and Immunology Book 290 · Springer Science & Business Media
Ebook
260
Pages
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About this ebook
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
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