The 21 papers presented here were carefully reviewed and selected from over 40 submissions. They highlight the latest advances in blockchain, artificial intelligence and their application domains, exploring innovative ideas, guidelines, theories, models, technologies, and tools, and identifying critical issues and challenges that researchers and practitioners will face in the near future. We wish to thank the sponsors: IEEE Systems Man and Cybernetics Society, Spain Section Chapter, and the IEEE Spain Section (Technical Co-Sponsor), IBM, Indra, Viewnext, Global Exchange, AEPIA, APPIA and AIR institute.