Fc Mediated Activity of Antibodies: Structural and Functional Diversity
Jeffrey V. Ravetch · Falk Nimmerjahn
Sep 2019 · Current Topics in Microbiology and Immunology Book 423 · Springer Nature
Ebook
150
Pages
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About this ebook
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
About the author
Jeffrey V. Ravetch
Theresa and Eugene M. Lang Professor
Department Leonard Wagner Laboratory of Molecular Genetics and Immunology
Rockefeller University
1230 York Avenue, Box 98
New York, NY 10021, USA
Falk Nimmerjahn
Professor for Immunology and Genetics
Chairman of the Institute of Genetics
Head of the Department of Biology
Department of Biology
University of Erlangen-Nuernberg
Erwin-Rommelstr. 3
91058 Erlangen, GermanyRate this ebook
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