This book constitutes the refereed proceedings of the 22nd International Symposium on Model Checking Software, SPIN 2015, held in Stellenbosch, South Africa, in August 2015. The 18 papers presented тАУ 14 regular papers and 4 tool or new idea papers тАУ were carefully reviewed and selected from 27 submissions. They cover the field between theoretical advances and practical considerations and are organized in topical sections such as abstraction, refinement, translation; B├╝chi automata and hashing; embedded systems; heuristics and benchmarks; SAT/SMT- based approaches; software validation and verification.