To ensure that the ERCs continue to be a source of innovation, economic development, and educational excellence, NSF commissioned the National Academies of Sciences, Engineering, and Medicine to convene a 1-day symposium in April 2016. This event featured four plenary panel presentations on: the evolving global context for center-based engineering research, trends in undergraduate and graduate engineering education, new directions in university-industry interaction, and emerging best practices in translating university research into innovation. This publication summarizes the presentations and discussions from the symposium.