New Worlds, New Horizons: A Midterm Assessment reviews the responses of NASA's Astrophysics program, NSF's Astronomy program, and DOE's Cosmic Frontiers program to NWNH. This report describes the most significant scientific discoveries, technical advances, and relevant programmatic changes in astronomy and astrophysics over the years since the publication of the decadal survey, and assesses how well the Agencies' programs address the strategies, goals, and priorities outlined in the 2010 decadal survey.