Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate

To resolve the disagreement, a two-generation reproductive study in mink was conducted. The Army asked the National Research Council (NRC) to independently evaluate the 1997 study and re-evaluate the drinking-water guideline for DIMP. This task was assigned to the Committee on Toxicology, which established the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, a multidisciplinary group of experts. The subcommittee evaluated the two-generation reproductive study as well as other studies relevant to the task. Data on the use of mink as a predictive model in toxicology were also reviewed. Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate is the subcommittee's report which shows that neither party was corrected in their DIMP guidelines. The report includes the subcommittee's evaluation and recommendations concerning the topic.