Nongenotoxic Carcinogenesis
A. Cockburn · L. Smith
mars 2013 · Ernst Schering Foundation Symposium Proceedings Livre 10 · Springer Science & Business Media
Ebook
240
Pages
reportLes notes et les avis ne sont pas vérifiés En savoir plus
À propos de cet ebook
"What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com mon mechanisms include hormonal imbalance resulting in thyroid tu mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book.
Attribuez une note à ce ebook
Faites-nous part de votre avis.
Informations sur la lecture
Téléphones intelligents et tablettes
Installez l'appli Google Play Livres pour Android et iPad ou iPhone. Elle se synchronise automatiquement avec votre compte et vous permet de lire des livres en ligne ou hors connexion, où que vous soyez.
Ordinateurs portables et de bureau
Vous pouvez écouter les livres audio achetés sur Google Play en utilisant le navigateur Web de votre ordinateur.
Liseuses et autres appareils
Pour pouvoir lire des ouvrages sur des appareils utilisant la technologie e-Ink, comme les liseuses électroniques Kobo, vous devez télécharger un fichier et le transférer sur l'appareil en question. Suivez les instructions détaillées du centre d'aide pour transférer les fichiers sur les liseuses électroniques compatibles.
