The 21 full papers presented together with 6 invited abstracts lectures and 2 tutorial abstracts in this volume were carefully reviewed and selected from 88 submissions. The conference focuses on the following topics: Mathematical programming, bi-level and global optimization, integer programming and combinatorial optimization, approximation algorithms with theoretical guarantees and approximation schemes, heuristics and meta-heuristics, game theory, optimal control, optimization in machine learning and data analysis, and their valuable applications in operations research and economics.