Rubin and Damjanov's latest volume of Pathology Reviews highlights the latest progress in the interface of biology and disease. Forefront techniques and experimental models that were once considered exotic or esoteric, are explored here in the context of understanding more fully the processes involved in human disease. Topics include: regulation of liver growth โข contractile cells in lungs โข mineral formation in bone โข folate metabolism โข the "riddle of the mast cell" โข HLA antigens โข interleukin 6 โข IgA nephropathy โข Goodpasture syndrome โข anti-basement membrane glomerulonephropathy โข molecular mechanisms of oncogenesis โข molecular diagnosis of cancer โข inhibition of intercellular communication in carcinogenesis โข DNA repair and its pathogenetic implications โข human and rat mammary tumorigenesis. Pathology Reviews โข 1990 is essential reading for everyone concerned with the mechanisms of disease.