Pharmacokinetic Challenges in Drug Discovery
O. Pelkonen · A. Baumann · A. Reichel
ມ.ນ. 2013 · Ernst Schering Foundation Symposium Proceedings ຫົວທີ 37 · Springer Science & Business Media
ປຶ້ມອີບຸກ
306
ໜ້າ
reportບໍ່ໄດ້ຢັ້ງຢືນການຈັດອັນດັບ ແລະ ຄຳຕິຊົມ ສຶກສາເພີ່ມເຕີມ
ກ່ຽວກັບປຶ້ມ e-book ນີ້
Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.
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