Phosphodiesterases as Drug Targets
Sharron H. Francis · Marco Conti · Miles D. Houslay
2011 оны 6-р сар · Handbook of Experimental Pharmacology 204-р ном · Springer Science & Business Media
Электрон ном
522
Хуудас
reportҮнэлгээ болон шүүмжийг баталгаажуулаагүй Нэмэлт мэдээлэл авах
Энэ электрон номын тухай
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Зохиогчийн тухай
STEFANO BASAGNI holds a PhD in computer science from the University of Milano, Italy, and a PhD in electrical engineering from the University of Texas at Dallas. He received his BSc degree in computer science from the University of Pisa, Italy, in 1991. Since January 2002, he has been an assistant professor of Computer Engineering in the Electrical and Computer Engineering Department of Northeastern University. MARCO CONTI received the Laurea degree in Computer Science from the University of Pisa, Italy. He is currently a senior researcher at the Informatics and Telematics Institute (IIT) of the Italian National Research Council (CNR). He served as program committee chair of IFIP-TC6 Conferences "Networking2002," and "PWC2003." He is on the editorial board of ACM Mobile Computing and Communications Review. SILVIA GIORDANO received her PhD from EPFL, Lausanne. She is currently coordinator of Wireless, Telecommunication and High Frequency at the University of Applied Science of Ticino (Switzerland), and working as scientific collaborator at IIT-CNR, Pisa (Italy). She is a technical editor of IEEE Communications Magazine. IVAN STOJMENOVIc received a PhD degree in mathematics from the University of Zagreb. He is currently full professor at the University of Ottawa (Canada). He is managing editor of the Journal of Multiple-Valued Logic and Soft Computing, and an editor of IEEE Transactions on Parallel and Distributed Systems, Parallel Processing Letters, and a few other journals. He recently edited the Handbook of Wireless Networks and Mobile Computing (Wiley, 2002).
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