Protein Folding Protocols
Yawen Bai
févr. 2008 · Methods in molecular biology Livre 350 · Springer Science & Business Media
Ebook
328
Pages
reportLes notes et les avis ne sont pas vérifiés En savoir plus
À propos de cet ebook
Protein Folding Protocols presents protocols for studying and characterizing steps and conformational ensembles populating pathways in protein folding from the unfolded to the folded state. It further presents a sample of approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. Protein folding is a crucial step in the transfer of genetic information from the DNA to the protein. The Genome Project has led to a huge number of available DNA sequences and, therefore, protein sequences. The Structural Genomics initiative largely aims to obtain “new” folds not currently present in the Protein Data Bank. Yet, the number of available structures inevitably lags behind the number of sequences. At the same time, an equally important problem is to find out the types and scope of dissimilar (nonhomologous) protein sequences that adopt a similar fold. Assembling data and comprehension of the sequence space of protein folds should be very useful in computational protein structure prediction. This would enhance the scope of homology modeling, which currently is the method of choice. Thus, experimental and theoretical studies on the relationship between sequence and structure are critical. Figuring out the relationship between sequence and structure would further assist in the prediction of fibril structures observed in protein misfolding diseases, and in figuring out the conformational changes and dynamics resulting from mutations. Protein folding is one of the most important and challenging problems in current molecular and chemical biology.
Attribuez une note à ce ebook
Faites-nous part de votre avis.
Informations sur la lecture
Téléphones intelligents et tablettes
Installez l'appli Google Play Livres pour Android et iPad ou iPhone. Elle se synchronise automatiquement avec votre compte et vous permet de lire des livres en ligne ou hors connexion, où que vous soyez.
Ordinateurs portables et de bureau
Vous pouvez écouter les livres audio achetés sur Google Play en utilisant le navigateur Web de votre ordinateur.
Liseuses et autres appareils
Pour pouvoir lire des ouvrages sur des appareils utilisant la technologie e-Ink, comme les liseuses électroniques Kobo, vous devez télécharger un fichier et le transférer sur l'appareil en question. Suivez les instructions détaillées du centre d'aide pour transférer les fichiers sur les liseuses électroniques compatibles.
