The 36 full papers presented in this volume were carefully reviewed and selected from 142 submissions. They deal with parallel and distributed computing in general, focusing on support tools and environments; performance and power modeling, prediction and evaluation; scheduling and load balancing; high performance architectures and compilers; data management, analytics and deep learning; cluster and cloud computing; distributed systems and algorithms; parallel and distributed programming, interfaces, and languages; multicore and manycore parallelism; theory and algorithms for parallel computation and networking; parallel numerical methods and applications; accelerator computing; algorithms and systems for bioinformatics; and algorithms and systems for digital humanities.