The 11 revised full papers presented were carefully reviewed and selected from 14 submissions. The contributions span the following broad categories: cross modality (PET/MR, PET/CT, CT/MR, etc.) image synthesis, simulation and synthesis from large-scale image databases, automated techniques for quality assessment images, and several applications of image synthesis and simulation in medical imaging such as image interpolation and segmentation, image reconstruction, cell imaging, and blood flow.