This volume contains papers presented on the 4th International Conference on Material Engineering and Manufacturing (ICMEM 2020), the 3rd International Conference on Materials Design and Applications (ICMDA 2020) and the 2nd International Conference on Biomacromolecules and Biomimetic Materials (ICBBM 2020) which were held successfully on remote in Tokyo, Japan during April 10-13, 2020. Presented articles are focused on fundamental and applied research in the field of materials properties, design of production technologies, and use of engineering materials, within the context of application in mechanical engineering and biomedicine.