Understanding the Human Fibrotic Diseases’ Genomics & Uncontrolled Wound Healing Response to Injury at Molecular Level.
Bu e-kitob haqida
Fibrotic disorders are implicated in nearly 45% of all deaths in the developed world.
Pathological fibrogenesis is associated with an uncontrolled wound healing response to injury in which tissue is replaced by deposition of excess extracellular matrix, leading to fibrosis and loss of organ function.
Classically, disease-specific triggers initiate site-specific injuries, which activate distinct cells that drive fibrosis in genetically susceptible individuals.
A plethora of genome-wide association studies, microarrays, exome sequencing studies, DNA methylation arrays, next-generation sequencing, and profiling of noncoding RNAs have been performed in patient-derived fibrotic tissue, with the shared goal of utilizing genomics to identify the transcriptional networks and biological pathways underlying the development of fibrotic diseases.
An attempt has been made in this E-Booklet to discus the fibrosing disorders of the Skin, Liver, Kidney, Lung, and Heart, systematically,
1. Characterizing the initial acute injury that drives unresolved inflammation,
2. Identifying genomic studies that have defined the pathologic gene changes leading to excess matrix deposition and fibrogenesis, and
3. Summarizing therapies targeting pro-fibrotic genes and networks identified in the genomic studies along with several relevant IMAGES for better understanding!
…Dr. H. K. Saboowala.
M.B.(Bom) .M.R.S.H.(London)
Muallif haqida
It is my passion to research for the Current/Recent Medical Topics and compile the E-Booklets as a reference to enrich the knowledge of busy Medicos at one CLICK, that too with an affordable price! Basically I am a General Physician and a Dermatologist, practicing in Mumbai (India) since last 45 years.
I’m inspired for this ardent process after getting an overwhelming response (from Medical Community throughout India) for my two E- Booklets titled-"Medical Palmistry" & "Medical Mycoses" donated (4,000 copies of each) to two Pharmaceuticals in India,-(a multinational giant pharma company) "GLENMARK PHARMA'' & "MICROLAB" respectively(both of these are available at Amazon.com.at an affordable price at present).
Moreover one of my E- Booklet titled-"CRISPR Cas-9" - An enzymatic Scissor has also attracted most of the readers throughout the world till day (>50 Copies have been sold within a year).
At present there are >300 interesting & informative and a safe research oriented E- Booklets are available at Amazon.com.at affordable prices .
In view of this I have published a catalogue titled"A Catalogue of a Elegant 200 compilation of E-Medical Booklets" enabling the readers to select the topic of choice and buy at leisure from amazon.com/author/dr.hakim_e-
......Dr. Hakim.K.Saboowala.
M.B.(Bom) MRSH (London)
