Understanding the potential Role of Trimethylamine N-Oxide(TMAO),a Gut generated Biomolecule, in the Pathogenesis of Atherosclerosis (AS) and Utility of TMAO-targeted Therapeutic Strategies for ℞ of AS.

· Dr.Hakim Saboowala
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Understanding the potential Role of Trimethylamine N-Oxide(TMAO),a Gut generated Biomolecule, in the Pathogenesis of Atherosclerosis (AS) and Utility of TMAO-targeted Therapeutic Strategies for ℞ of AS.


Atherosclerosis (AS) is considered a chronic inflammatory disease initiated by vascular endothelial inflammatory injury

        Accumulating evidences have indicated a close association between high plasma level of Trimethylamine N-oxide (TMAO), a biologically active molecule generated by the gut microbiota and the risk of developing atherosclerosis (AS).

        Both observational and experimental studies suggest that TMAO can cause endothelial inflammatory injury.

        However, a clear mechanistic link between TMAO and vascular inflammation of AS is not yet summarized.

       Thus, an endeavor has been made in this E-Booklet to discuss the association between TMAO and AS and focus on the potential role of TMAO in endothelial inflammatory injury and to analyze the utility of TMAO-targeted Therapeutic Strategies for the treatment of AS.

…Dr. H. K. Saboowala.

                    M.B.(Bom) .M.R.S.H.(London)

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    It is my passion to research for the Current/Recent Medical Topics and compile the E-Booklets as a reference to enrich the knowledge of busy Medicos at one CLICK, that too with an affordable price!

       Basically, I am a General Physician and a Dermatologist, practicing in Mumbai (India) since last 45 years.

      I am inspired for this ardent process after getting an overwhelming response (from Medical Community throughout India) for my two E- Booklets titled-"Medical Palmistry" & "Medical Mycoses" donated (4,000 copies of each) to two Pharmaceuticals in India,-(a multinational giant pharma company) "GLENMARK PHARMA'' & "MICROLAB" respectively(both of these are available at Amazon.com.at an affordable price at present).

     Moreover, one of my E- Booklet titled-"CRISPR Cas-9" - An enzymatic Scissor has also attracted most of the readers throughout the world till day (>50 Copies have been sold within a year).

      At present there are >300 interesting & informative and a safe research-oriented Multi-Disciplinary E- Booklets are available at Amazon.com.at affordable prices.

      In view of this I have published a catalogue titled"A Catalogue of a Elegant >300 compilation of E-Medical Booklets" enabling the readers to select the topic of choice and buy at leisure from amazon.com/author/dr.hakim_e-medicalbooks.

......Dr. Hakim. K. Saboowala.                      

                                   M.B.(Bom) M.R.S.H.(London)

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