This operational guide addresses important infection prevention and control (IPC) measures that should be implemented during a Crimean-Congo haemorrhagic fever (CCHF) outbreak/case. IPC measures are based on the principles of standard and transmission-based precautions. When implemented effectively, IPC measures can prevent or control transmission, keeping patients, health and care workers and visitors/caregivers safe. Key advice in this guide includes ensuring those with a suspected or confirmed case of CCHF are isolated in single bedroom; utilizing contact precautions with additional personal protective equipment based on risk-assessment. In addition to this, airborne precautions should be initiated when performing aerosol-generating procedures. This guide also includes guidance on investigating and reporting health-care-associated infections of CCHF, outbreak management, health and care worker endure management and setting-specific considerations for surgical and operating room settings.