An Integrated Analysis of Microbiomes and Metabolomics

· ACS In Focus Book 31 · American Chemical Society
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100
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About this ebook

Because the microbial community is dynamic, an individual’s microbiota at a given time is varied, and many factors, including age, host genetics, diet, and the local environment, significantly change the microbiota. Thus, microbiome researchers have naturally expanded their research to look for insights into the interaction of the microbiome with other “omics”. Metabolites (small molecules) are the intermediate or end products of metabolism. Metabolites have various functions. The microbial-derived metabolites play an important role in the function of the microbiome. Thus, the advancement in microbiome studies is becoming particularly critical for the integration of microbial DNA sequencing data with other omics data, especially microbiome-metabolomics integration.

About the author

Yinglin Xia is a Research Associate Professor in the Department of Medicine at the University of Illinois at Chicago (UIC). He was a Research Assistant Professor in the Department of Biostatistics and Computational Biology at the University of Rochester (Rochester, NY) before joining AbbVie (North Chicago, IL) as a Clinical Statistician. He joined UIC as a Research Associate Professor in 2015. Dr. Xia has successfully applied his statistical study design and data analysis skills to clinical trials, medical statistics, biomedical sciences, and social and behavioral sciences. He has published more than 120 statistical methodology and research papers in peer-reviewed journals. He serves on the editorial board of 9 scientific journals and has served as a reviewer for over 90 scientific journals. Dr. Xia is the lead author of Statistical Analysis of Microbiome Data with R (Springer Nature, 2018), which was the first statistics book in microbiome study.

Jun Sun is a tenured Professor of Medicine at the University of Illinois at Chicago. She is an elected fellow of the American Gastroenterological Association (AGA) and American Physiological Society (APS). She chairs the AGA Microbiome and Microbial Therapy section. She is an internationally recognized expert on microbiome and vitamin D receptor in inflammation. Dr. Sun has published over 210 scientific articles in peer-reviewed journals and 6 books on microbiome. She is on the editorial boards of more than 10 peer-reviewed international scientific journals and serves on the study sections for the national and international research foundations. Dr. Sun is a believer of scientific art and artistic science. She enjoys writing her science papers in English and poems in Chinese. Her poetry collection 《让时间停留在这一刻》 (“Let Time Stay Still at This Moment”) was published in 2018.

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