His Last Bow and Others: Sherlock Holmes Collections

 Doyle struggled to find a publisher for his work. His first work featuring Sherlock Holmes and Dr. Watson, A Study in Scarlet, was taken by Ward Lock & Co on 20 November 1886, giving Doyle £25 for all rights to the story. The piece appeared later that year in the Beeton's Christmas Annual and received good reviews in The Scotsman and the Glasgow Herald.

Holmes was partially modelled on his former university teacher Joseph Bell. In 1892, in a letter to Bell, Doyle wrote, "It is most certainly to you that I owe Sherlock Holmes ... round the centre of deduction and inference and observation which I have heard you inculcate I have tried to build up a man." and, in his 1924 autobiography, he remarked, "It is no wonder that after the study of such a character I used and amplified his methods when in later life I tried to build up a scientific detective who solved cases on his own merits and not through the folly of the criminal. Robert Louis Stevenson was able, even in faraway Samoa, to recognise the strong similarity between Joseph Bell and Sherlock Holmes: "My compliments on your very ingenious and very interesting adventures of Sherlock Holmes. ... can this be my old friend Joe Bell?" Other authors sometimes suggest additional influences—for instance, the famous Edgar Allan Poe character C. Auguste Dupin. Dr. (John) Watson owes his surname, but not any other obvious characteristic, to a Portsmouth medical colleague of Doyle's, Dr James Watson.

A sequel to A Study in Scarlet was commissioned and The Sign of the Four appeared in Lippincott's Magazine in February 1890, under agreement with the Ward Lock company. Doyle felt grievously exploited by Ward Lock as an author new to the publishing world and he left them. Short stories featuring Sherlock Holmes were published in the Strand Magazine. Doyle wrote the first five Holmes short stories from his office at 2 Upper Wimpole Street (then known as Devonshire Place), which is now marked by a memorial plaque.
Sherlock Holmes statue in Edinburgh, erected opposite the birthplace of Doyle which was demolished c.1970

Doyle's attitude towards his most famous creation was ambivalent. In November 1891 he wrote to his mother: "I think of slaying Holmes,... and winding him up for good and all. He takes my mind from better things." His mother responded, "You won't! You can't! You mustn't!". In an attempt to deflect publishers' demands for more Holmes stories, he raised his price to a level intended to discourage them, but found they were willing to pay even the large sums he asked. As a result, he became one of the best-paid authors of his time.

In December 1893, to dedicate more of his time to his historical novels, Doyle had Holmes and Professor Moriarty plunge to their deaths together down the Reichenbach Falls in the story "The Final Problem". Public outcry, however, led him to feature Holmes in 1901 in the novel The Hound of the Baskervilles.

In 1903, Doyle published his first Holmes short story in ten years, The Adventure of the Empty House, in which it was explained that only Moriarty had fallen; but since Holmes had other dangerous enemies—especially Colonel Sebastian Moran—he had arranged to also be perceived as dead. Holmes was ultimately featured in a total of 56 short stories—the last published in 1927—and four novels by Doyle, and has since appeared in many novels and stories by other authors.

Jane Stanford compares some of Moriarty's characteristics to those of the Fenian John O'Connor Power. 'The Final Problem' was published the year the Second Home Rule Bill passed through the House of Commons. 'The Valley of Fear' was serialised in 1914, the year Home Rule, the Government of Ireland Act (18 September) was placed on the Statute Book