Wholesale distribution plays a significant role in the economy, accounting for more than 400,000 establishments with combined sales of about $9 trillion in the U.S. alone, according to a First Research report. Wholesale distributors are also experiencing rapid change due to a number of factors: new competition, the growth of eCommerce, and rising customer expectations, among others. Here’s what you need to know about wholesale distribution, including key benefits, challenges, and examples — plus tips for running a successful distribution business.