G Protein-Coupled Receptors: Structure, Signaling, and Physiology
Sandra Siehler · Graeme Milligan
Sep 2010 · Cambridge University Press
Ebook
447
Pages
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About this ebook
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
About the author
Dr Siehler is a Research Investigator at the Novartis Institute for Biomedical Research in Basel, Switzerland. Dr Siehler is a member of the American Society for Pharmacology and Experimental Therapeutics and the British Pharmacological Society.
Dr Milligan is Professor of Molecular Pharmacology at the University of Glasgow. He is actively involved in numerous associations, such as the Biochemical Society and British Pharmacological Society. Dr Milligan was awarded the Ariens Award for Pharmacology from the Dutch Pharmacological Society in 2006.
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